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Collectively, our structures reveal an ago-PAM mechanism for GLP-1R, in which the rearrangement of the conserved polar network is trigged by TM6 movement and stabilized by the ECD-TMD interaction

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BJOG 2013;120:46371

doi: 10.1002/ptr.2761 182 WeinSBehmNPetersenRKKristiansenKWolfframS