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In the STEP 1 trial, semaglutide produced substantial weight loss, of which approximately 30% was attributed to lean tissue, while fat loss predominated [21, 22]

This minimal difference between year one and year two confirms that the medication maintains weight loss over extended treatment without significant regain

Maintaining healthy eating habits and regular physical activity can help support long-term weight management

Yu Z, Grams ME, Ndumele CE, Wagenknecht L, Boerwinkle E, North KE, et al

Feb 5, 2026 Experienced researchers know something beginners do not about retatrutide dosing

He rises at 4.30am, eats all his meals before 11am, and goes to bed alone at 8.30pm, without exception