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The highest dose of 3 mg/kg/day resulted in dystocia in 8/12 female rats secondary to maternal toxicity and significant decreases in serum calcium levels
In phase 2 clinical trials, this drug improved body weight, body fat, and glycated hemoglobin (HbA1c) levels in people with obesity, with or without T2D
Simultaneously, these medications suppress glucagon secretion from pancreatic alpha cells, further contributing to improved glycemic control
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doi:10.1080/00365513.2016.1271907 17
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