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These include: Nausea and vomiting Diarrhoea Abdominal discomfort Constipation When patients experience significant nausea or gastrointestinal distress, the body's autonomic nervous system may respond with sweating, particularly cold sweats or diaphoresis

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Some researchers theorize that tirzepatide's biased agonism, particularly its stronger GIP activity relative to GLP-1 activity, may produce a different side effect profile that certain people tolerate better

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The Food and Drug Administration (FDA) sanctioned exenatide in 2005 in parenteral formulations as an adjunct to diet and exercise for the amelioration of blood glucose levels in adults with T2DM