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a 25% target) at 68 weeks, well below expectations

Ruder, K

Available from: Wang Y, Song X, Zhuang L, Lang H, Yu L, Yan X, et al

Discussion Treatment of T2D patients with GLP-1 analogues results in various beneficial effects, including improvement in -cell function and glucose homeostasis 7

Structures of the glucagon receptor (GCGR), the closest homolog of GLP-1R, have revealed key differences between the peptide-free and peptide-bound states, including an interesting -sheet motif in the peptide-free structure comprised of the stalk region and extracellular loop 1 ( ECL1) 9,14

"Retatrutide Clinical Development: Safety and Efficacy in Phase 2 Trials." Clinical Endocrinology and Metabolism Review, 2024