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Description
Retatrutide and semaglutide work differently

Tirzepatide may offer more significant weight loss and improved glucose control compared to semaglutide, as it targets both GIP and GLP-1 receptors

N Engl J Med 383:22192229

Incorporating Semaglutide into a Comprehensive Weight Management Plan Semaglutide is most effective when you use it with a full weight management plan
10.1073/pnas.0237106100 Proc

Your bodys natural GLP-1 secretion responds to several inputs