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This is the single most effective strategy

In some cases, loose skin can cause irritation and lead to infection, but for many people, the effects are less severe and more of an unwanted nuisance

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Moreover, in August 2025, Wegovy received accelerated approval to treat metabolic-associated steatohepatitis (MASH) in adults with moderate-to-advanced liver fibrosis (but not cirrhosis)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 133.Finan B., Yang B., Ottaway N., Stemmer K., Muller T.D., Yi C.X., Habegger K., Schriever S.C., Garcia-Caceres C., Kabra D.G., et al