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However, genetics influence your susceptibility: the PlexusDx Precision Peptide Genetic Test identifies variants in GLP1R and MC4R that predict your individual risk, allowing your doctor to plan your dose escalation more strategically from day one

When activated, GLP-1 slows digestion, increases the feeling of fullness, and supports balanced blood sugar levels by making the body more sensitive to insulin

Those findings are not necessarily contradictory

GLP-1 receptor agonists slow gastric emptying and alter digestive timing throughout the gastrointestinal tract

These predispositions do not determine medication efficacy but may help contextualize variation in weight loss response across individuals

An increase in serotonergic 5-HT2C receptor activity seemingly increases effects of GLP-1 agonism, and increased synaptic serotonin is simultaneously associated with decreased sexual response and desire