history of glp-1 drugs Market Size to Hit USD 132.79 Bn by 2035 Structural pharmacology and mechanisms of
Description
Unmet target Despite the glycaemic efficacy and related benefits of GLP-1RAs, some patients may not achieve their target HbA 1c after four to six months of use, by which time the full effects of the medication would be manifest
It can also result in serious complications, including bezoars, severe dehydration, and unpredictable blood sugar changes
This mechanism has been validated in multiple cardiovascular outcome trials, with semaglutide showing a 20% reduction in major adverse cardiovascular events in the SUSTAIN-6 study
Lhteenvuo M, Tiihonen J, Solismaa A, Tanskanen A, Mittendorfer-Rutz E, Taipale H
eClinicalMedicine 74 , 102726 (2024)
Marx N, Federici M, Schtt K et al (2023) 2023 ESC Guidelines for the management of cardiovascular disease in patients with diabetes
