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Conversely, some patients find their thyroid medication requirements stable throughout semaglutide treatment

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Wegovy, approved by the FDA in 2021 for chronic weight management, demonstrated an average 15% body weight loss over 68 weeks in clinical studiesmaking it one of the most effective non-surgical weight-loss treatments available 4

However, chronic stimulation of these paracrine myofibroblast pathways in IBD raises theoretical safety concerns regarding stricturing, fibrosis risk, and the necessity for rigorous dysplasia surveillance, which remain critical hurdles for long-term clinical development

Clin Drug Investig 2019;39:805-819