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GABA neurons act as the brains brake system that helps control neural activity

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Mechanism of Action Retatrutide works as a triple agonist, simultaneously activating three receptors involved in metabolic regulation: the glucagon receptor (GCGR), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon-like peptide-1 receptor (GLP-1R)

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Preclinical studies using GLP-1-estrogen conjugates have shown enhanced metabolic and neuroprotective outcomes, accompanied by reduced systemic hormonal exposure, suggesting a viable therapeutic strategy