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The SUSTAIN 6 trial similarly showed cardiovascular benefit despite some transient blood pressure elevation during initiation

References Lau, D., Erichsen, L., Francisco, A., Satylganova, A., Roux, C., McGowan, B., Pedersen, S., Pietilinen, K., Rubino, D., & Batterham, R

Its not usually the first step, but it can be a powerful tool for those who are ready for a more aggressive approach

However, its drawback lies in its delivery method, requiring infusion via a pump directly into the cerebrospinal fluid to reach Ca v 2.2 channels located in spinal cord neurons

Conclusion Clinical trial data from large, controlled studies demonstrate the efficacy and safety of GLP-1 agonists in terms of A1C reduction, beneficial effects on body weight, and a low risk for hypoglycemic events when used as monotherapy

Stop taking aspirin temporarily and contact your doctorit could be gastritis or a sign that your specific combination isn't tolerated