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Both the 2016 consensus statement of the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) on management of type 2 diabetes and the 2016 American Diabetes Association (ADA) standards recommend adding on GLP-1 RAs to patients not meeting treatment goals with basal insulin

Wang J, Campos AI, Garca-Marn LM, et al

HR 1.19, 95% CI 0.91.58), but not for the other DPP-4 inhibitors as in the TECOS study for sitagliptin (HR 1.00, 95% CI 0.831.20) or the CARMELINA study for linagliptin (HR 0.90, 95% CI 0.741.08) (57, 62, 64, 65, 68)

2021, doi: 10.3389/fphar.2021.731453

Scott, R., Minnion, J., Tan, T

Additionally, high patient awareness, advanced healthcare infrastructure, and major pharmaceutical presence, along with direct-to-consumer and telehealth models, are enhancing nationwide access to GLP-1 therapies