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While lipid tolerance was unaffected, the distinct kinetics of excursion and clearance were not assessed

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Our bodies are made of proteins

In STEP 4, participants continued with Semaglutide for an additional 48 weeks

APOE 2 and APOE 3 mediate rapid A clearance by interacting with LRP-1, whereas APOE 4 has a higher affinity to very low-density lipoprotein receptor (VLDR) resulting in slower clearance of A and increased accumulation in the brain (van Assema et al., 2011)

During enrollment, patients may select the option they prefer, and a licensed medical provider will confirm which formulation is appropriate for their care