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Biochem Pharmacol 229:116471 [DOI] [PubMed] [Google Scholar] Kelly CA, Sipos JA (2024) Approach to the patient with thyroid nodules: considering GLP-1 receptor agonists

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This means it mimics two different natural hormones in your body: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)

Appetite usually returns gradually over 24 weeks rather than immediately, though hunger cues intensify noticeably within days

Occasional nausea is common with GLP-1 RAs, but persistent vomiting (GLP-1 related or not) can deplete electrolytes significantly

Retatrutide is an investigational once-weekly injection developed by Eli Lilly