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Liraglutide increased eNOS phosphorylation in human endothelial cells, enhancing vascular relaxation [26]

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GLP-1 medicines may have anti-inflammatory effects Researchers are also studying whether GLP-1 medicines may directly affect immune cells and inflammatory pathways

[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Shibasaki T, Takahashi H, Miki T, Sunaga Y, Matsumura K, Yamanaka M, et al

The beneficial effect of tirzepatide on hsCRP, a biomarker of systemic inflammation, YKL-40, a proinflammatory cytokine, and ICAM-1, a biomarker of endothelial dysfunction, was already detectable at 4 weeks, consistent with the salutary effects of GIP and GLP-1 on inflammation and atherosclerosis in experimental models [84,85,86]