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This long game means lifestyle education and the ongoing bolstering of behavior change, which is bloody hard but do-able if we employ smart, clever, insightful design teams who deeply understand whats underneath patients lives and daily choices

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Although, in the last 10 years, the use of GLP-1 RAs, especially semaglutide and liraglutide, has increased, its clinical implications and how it affects metabolic parameters have yet to be fully consolidated

Clinical trials (ten studies, 419 participants) using doses from 400 mg to 10 g over 21 days to 20 months show consistent reductions in fasting glucose, post-meal glucose, and HbA1c. In diabetic animal studies, gymnema increased proglucagon gene expression (a precursor for GLP-1) and insulin gene activity, suggesting it may help amplify endogenous GLP-1 production

The findings are based on analysis of data from 2.4 million participants.

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