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Incretin based therapies with glucagon-like peptide-1 receptor agonists (GLP-1RA) are already established in the treatment of type 2 diabetes

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The growing prevalence of metabolic disease, CKD, and ASCVD have prompted investigation into the role of GLP-1R agonists in mitigating cardiovascular and metabolic risks, particularly within the framework of Cardiovascular-Kidney-Metabolic (CKM) Syndrome, irrespective of diabetic status

Van DerSchootA, Drysdale C, Whelan K,DimidiE. The effect offibersupplementation on chronic constipation in adults: An updated systematic review and meta-analysis of randomized controlled trials.AmJ ClinNutr.2022;116:953-969. doi:10.1093/ajcn/nqac184