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Statements Author contributions SN: Conceptualization, Writing review and editing, Formal Analysis, Writing original draft, Methodology, Data curation

It is important to emphasize that these findings are very limited and presented in animal and in vitro models

As of now, neither Ozempic nor any GLP-1 drug is formally approved for routine use in cats or dogs

Retatrutide is studied in research on triple incretin pharmacology, hepatic fat metabolism, NASH/MASH resolution, energy expenditure physiology, brown adipose tissue activation, and multi-receptor agonist design principles

Compounded semaglutide is dramatically cheaper than brand-name Ozempic because it avoids patent premiums (no monopoly pricing during patent protection), eliminates brand-name marketing expenses (billions spent on advertising and sales), uses direct-to-consumer distribution (cutting out multiple middlemen and markups), employs simpler packaging (standard vials versus sophisticated pen devices), operates with lower overhead (efficient telehealth models versus traditional pharmaceutical infrastructure), and doesnt need to recover research and development costs (using already-developed pharmaceutical ingredients)