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Therefore, clinicians should prioritize gradual dosing, patient education, and individualized care

People who are pregnant, trying to become pregnant, or breastfeeding should not rely on investigational-drug information without medical guidance

[8] [9] Both medication classes can influence metabolic parameters, though through different mechanisms

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As patients and clinicians explore these medications' broader metabolic impacts, questions arise about potential effects on cortisolthe stress hormone linked to central weight gain and insulin resistance

In terms of microbial metabolism, melatonin significantly reduces the relative abundance of the microbiome in the cysteine and methionine metabolism and peptidoglycan biosynthesis pathway in the restraint stress mouse model, while increasing the relative abundance of the microbiome in the tryptophan metabolism, aminobenzoic acid degradation, renin angiotensin system, -aminobutyric acid ergic synapses and type II diabetes pathway (Lin et al., 2021)