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The rate of pancreatitis was similar in patients receiving GLP-1 RAs and those who did not receive GLP-1 RAs (0.1% vs

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The difference stems from direct appetite circuit engagement rather than metabolic optimization alone

Consistent with previous work [15, 16], we found that in the absence of GLP-1 production, GIP is sufficient to maintain improved glucose tolerance after DPP-4 inhibitor administration

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