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The risk of MACE was also significantly reduced in consecutive studies (Harmony Outcomes [18], REWIND [19], AMPLITUDE-O [20])

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Retatrutide is a triple receptor agonist that has been studied for its interaction with the GLP-1 , GIP , and glucagon receptors, making it an active area of metabolic and obesity-related research

In summary, convergent evidence from both preclinical and clinical research underscores the capacity of GLP-1RAs to interact with neural circuits that govern reinforcement and motivation, networks that are also targeted by drugs of abuse

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