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1 Cardiovascular disease (CVD) is the most prominent cause of morbidity and mortality among patients with T2D

J Physiol 535(Pt 1):301311 Simonson M, Boirie Y, Guillet C (2020) Protein, amino acids and obesity treatment

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For all these effects, different benefits have been attributed to DPP-4is (including improvement of oxidative stress, inflammation, fibrosis and apoptosis, endothelial function, and tissue reparation), related to renal protection and a variety of cardiovascular and metabolic clinical conditions beyond T2D, including hypertension, calcified aortic valve disease, atherosclerosis, and heart failure (HF) [47,68]