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While many studies have shown that dual agonists (GLP-1R/GIPR agonists) and tri-agonists (GLP-1R/GIPR/GCGR agonists) improve glycemia and body weight in amounts unprecedented by the single agents (Nauck & D'Alessio 2022), only a few have investigated their role in cardiovascular outcomes

Por su parte, el cido clorognico presente en el caf ha sido asociado con incrementos agudos de GLP1 en humanos tras tomarlo, posiblemente por retraso del vaciado gstrico o interaccin con clulas L

So, as I said, women with endometriosis, they might be 40 to 60% more likely to develop cardiovascular disease

As longevity medicine increasingly focuses on preserving physiological function rather than merely extending lifespan, immune optimization has become a major therapeutic target

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Exenatide, the first GLP-1RA approved in 2005, demonstrated clinical efficacy but its low homology with human GLP-1 and gastrointestinal side effects restricted widespread use (Muttenthaler et al., 2021)