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Phase 2 NEJM titration (still common in research) Phase 2 retatrutide titration schedule Phase Initiation Weeks Weeks 1-4 Weekly Dose 1 mg Phase Early escalation Weeks Weeks 5-8 Weekly Dose 2 mg Phase Mid escalation Weeks Weeks 9-12 Weekly Dose 4 mg Phase High escalation Weeks Weeks 13-16 Weekly Dose 8 mg Phase Maximum Weeks Weeks 17+ Weekly Dose 12 mg Source: Jastreboff et al., NEJM 2023

Relationship of Glicentin to Proglucagon and Glucagon in the Porcine Pancreas

& Ohlsson, C

novel approaches are desirable

If we rely on a one-size-fits-all approach, we risk harming patients by promoting muscle loss or triggering nutritional deficiencies

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