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Tirzepatide contains a C20 unsaturated di-acid acyl chain to affect albumin binding , and the overall properties of the molecule enable once-weekly dosing

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Hathaway et al 11 showed in a single-center 2024 cohort study comparing semaglutide with non-GLP-1RA antidiabetic medications that semaglutide was associated with increased risk of NAION in 403 matched patients with type 2 diabetes (HR, 4.28 [95% CI, 1.62-11.29]) and 613 matched patients with obesity (HR, 7.64 [95% CI, 2.21-26.36]), with a temporal association observed within the first year

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