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doi: 10.3390/ph18010027

Some people barely notice side effects, while others, like Schumer, can experience side effects based on their unique biology, dosage, or even specific genes

The high concentration of leptin in the circulation of obese patients causes the desensitization of leptin receptors in the hypothalamus and then a secondary reduction in the secretion of GnRH and gonadotropins

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[DOI] [PubMed] [Google Scholar] 73.Abbott CR, Monteiro M, Small CJ, Sajedi A, Smith KL, Parkinson JR, Ghatei MA, Bloom SR

A potential increased risk of thyroid C-cell tumors (based on animal studies, and has not been confirmed in people)