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Tolerability can depend on dose pace, meal size, hydration, protein, fiber, reflux history, medication history, and individual response

But the null finding is notable because it suggests that GLP-1 appetite suppression may already be near the ceiling of what appetite reduction can achieve, leaving little room for phentermine to add benefit

According to the SURMOUNT trials, meaningful weight loss continues to accumulate over time, with greater effects seen at higher maintenance doses (1015 mg weekly)

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The SURMOUNT-5 Phase IIIb double-blind, randomized study involved 751 participants from the US and Puerto Rico with obesity or overweight conditions with at least one weight-related medical problem and without diabetes

Theyll typically need to submit documentation, including your diagnosis and a proposed treatment plan