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Retatrutide (Eli Lilly) and CagriSema (Novo Nordisk) represent different approaches to the same goal: achieving weight loss approaching bariatric surgery without the scalpel

What Did the Research Actually Find

Traditionally, the treatment of metabolic hypogonadism in patients with obesity has relied on testosterone replacement therapy, primarily due to the challenges of achieving substantial weight loss through lifestyle changes alone in real-world settings

The honest summary: per-compound trial data are strong

Surg Endosc 38 (Suppl 1), 1103 (2024)

A 2023 study investigated the occurrence of VTE in 2+ years of medical claims data comparing those who took oral CEE/MPA (what was used in the WHO) with those who took oral 17-beta estradiol/micronized progesterone