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Another reason, she added, is manufacturing concerns, which might include contamination of the drug or inconsistency in its formulation

Obesity not only significantly increases the risk of developing T2DM but also exacerbates disease severity, with obese individuals being approximately seven times more likely to develop diabetes than those with a normal body weight (22)
This translated into a significantly higher likelihood of achieving the conventional glycemic target of HbA1c 30, those randomized to tirzepatide experienced 36 adjudicated cardiovascular deaths or heart failure worsening events versus 56 in the placebo group, representing a 38% reduction primarily driven by fewer heart failure exacerbations

But issues can arise e.g., impurities, immunogenicity to cause concern
Thats when some researchers theorized that resveratrol in red wine might be related to low coronary heart disease levels in France (Renaud, 1992)