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The progression from single to dual to triple agonism has produced measurable advances in clinical research outcomes, and the category continues to evolve as additional compounds enter clinical development

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Documented Outcomes Prescription semaglutide and tirzepatide have undergone Phase 3 randomized controlled trials demonstrating average weight loss of 10-22 percent over 68 weeks

The equation would start to balance if employers were able to keep the costs of GLP-1s down

doi: 10.2337/dc06-2089

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