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These findings increase the clinical relevance of liver endpoints in obesity pharmacotherapy, while also underscoring the limits of direct cross-trial comparison across differences in disease stage, endpoint definition and trial design Weight regain after treatment discontinuation deserves particular emphasis

Thyroid hormones profoundly influence basal metabolic rate, thermogenesis, and energy expenditure, making thyroid status a critical factor when evaluating any weight management intervention
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Dostert P, Benedetti MS, Poggesi I

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