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The increased risk of amputation seen in the large, long-term Canagliflozin Cardiovascular Assessment Study (CANVAS) trial for canagliflozin, and select observational studies, merits further research but overall, there is currently no consistent evidence of SGLT2i exposure and increased risk of amputation

For a broader explanation of GLP-1 treatment, you can read TrimRxs 2026 breakdown of what GLP-1 means

Your blood sugar should start to drop during the first week of taking it

Whilst several observational studies and case reports have documented improvements in psoriasis severity among patients treated with GLP-1 medications, these findings require cautious interpretation

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In studies, people using Semaglutide for weight loss saw an average weight reduction of 15-20% of their body weight