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Patients in their 40s, 50s, and 60s often hit a metabolic wall: weight gain that did not happen at 30, fasting glucose climbing into the high-90s or low-100s, fatigue that does not match their workload, and a feeling that their body is no longer responding to the things that used to keep them lean

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[18,34] Metabolic disorders such as obesity and diabetes frequently involve gut dysbiosis, which can increase systemic inflammation and worsen insulin resistance

Nature 630 , 695703 (2024)

Wang K, Hu J, Luo T, et al

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