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Ridker PM, Everett BM, Thuren T et al (2017) Antiinflammatory therapy with canakinumab for atherosclerotic disease

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Cost-effectiveness analysis A 2025 cost-effectiveness study published in PubMed found that tirzepatide was dominant over liraglutide from a UK healthcare perspective, meaning it produced both better outcomes and lower costs

Its whether its actually worth it

Further corroborating the potential protection against GRK/arrestin-mediated desensitization via continuous trafficking between the plasma membrane and the cytoplasmis another study showing that the interaction of arrestin2 with the GLP-1R is very transient, i.e., the GLP-1R is a class A GPCR in terms of arrestin binding [37]
