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GLP-1R Knockout Mice Studies investigating the effect of GLP-1R knockout/inactivation have generated some interesting observations

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Wharton hopes the advent of these medications will help to destigmatize chronic obesity among doctors, to clarify that this is a treatable health issue, not a flaw of character

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GLP-1RAs have positive effects on several CV risk factors (glycemic control, body weight, blood pressure, fasting, and postprandial lipoproteins) and it appears that the GLP-1RAs that induced the largest reductions in HbA 1c , body weight, and systolic blood pressure were also those associated with CV-event reduction

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Men with waist circumference over 40 inches and women over 35 inches show increased cardiovascular and metabolic disease risk

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Inaccurate mixing can lead to increased side effects if the dose is too high, or a lack of progress if the dose is too low

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