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GLP-1R Knockout Mice Studies investigating the effect of GLP-1R knockout/inactivation have generated some interesting observations

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Wharton hopes the advent of these medications will help to destigmatize chronic obesity among doctors, to clarify that this is a treatable health issue, not a flaw of character
GLP-1RAs have positive effects on several CV risk factors (glycemic control, body weight, blood pressure, fasting, and postprandial lipoproteins) and it appears that the GLP-1RAs that induced the largest reductions in HbA 1c , body weight, and systolic blood pressure were also those associated with CV-event reduction

Men with waist circumference over 40 inches and women over 35 inches show increased cardiovascular and metabolic disease risk

Inaccurate mixing can lead to increased side effects if the dose is too high, or a lack of progress if the dose is too low
