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A recombinant human glucagon-like peptide (GLP)-1albumin protein (albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis

As recent studies show the amount of people taking glucagon-like peptide-1 receptor agonists (GLP-1 agonists) for weight loss, and not for managing type 2 diabetes as originally used, researchers have been examining these medications for potential positive and negative side effects

Most of the subjects included in the available RCTs are PCOS patients with severe obesity, which do not reflect the entire clinical spectrum of PCOS encountered in clinical practice

Surprisingly, the SURMOUNT-5 trial found that fewer people discontinued tirzepatide due to side effects (2.7%) compared to semaglutide (5.6%)

It should support a lifestyle plan, not replace one

doi: 10.1016/S2213-8587(22)00349-7 [DOI] [PubMed] [Google Scholar] 217.Scheen AJ, Paquot N, Lefbvre PJ