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Clinical evidence shows modest effects on weight loss

Multiple generic manufacturers have filed Paragraph IV certifications

But to date, Wegovy has performed the best: in a Phase 3 trial, people given Wegovy alongside lifestyle counseling lost about 15%, on average, of their starting weight, compared with about 2.5% weight loss in people given a placebo and counseling

Figure 4, Panel D, presents a forest plot of HRs for non-fatal MI, illustrating a numerically lower point estimate for tirzepatide compared to the GLP-1RA class

People with kidney disease taking Ozempic should be closely monitored, because any type of rapid weight loss or dehydration can cause acute kidney injury, and people with preexisting kidney disease are at a higher risk of developing this complication