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A recent paper published in The Lancet showed that nearly 20% of participants in lifestyle interventions without medications gain weight, around 40% lose between 1-10% of their body weight, and just 13% lose more than 10%
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A balanced diet such as the Mediterranean diet can help with this

these medications are not reviewed or approved by the FDA for safety or effectiveness

Tirzepatide, in particular, offers promise as a therapy that could help address the rising tide of liver-related mortality, while also improving broader health outcomes in high-risk populations

If you have not tried standard titration with a 2mg starting dose and 4-week escalation intervals, you have not given weekly dosing a fair chance
