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medRxiv [Preprint] (2020), 2020.09.01.20185850

Interestingly, higher incidence of diabetic retinopathy (DR) complications was noted in patients taking semaglutide (3.0%) compared to placebo (1.5%) in clinical trials, with greater risk in those with a history of DR [32]

Moreover, IL-6/STAT3 activation can impair innate antitumor immunity by suppressing the activity of NK cells [175]

Pancreatic polypeptide inhibits somatostatin secretion

While effective, they come with notable side effects, including nausea, digestive issues and some serious issues : Vision Impairment Alert Semaglutide, a widely used GLP-1 receptor agonist, has been linked to a significantly higher rate of reported vision problems