glp-1 drugs adverse effects A Retrospective Comparative Analysis of Cutaneous Reactions in Agonist Therapies - JDDonline Adverse effects of GLP-1 class

10.1111/dom.12591

Five clinical trials (SURPASS 1-5 trials) conducted in patients with T2DM showed that tirzepatide at 5-15 mg per week could reduce body weight (5.4-11.7kg), which was never seen with a single drug (129)

12 The substitution of GLP-1 Thr 13 or GIP Ile 7 with Ala obviously decreased their receptor-activating activities 25,26 and the substitution of GIP Ile 7 with Thr decreased its cAMP activity (pEC 50 : 9.769.58;Emax: 9.918.90)

Retatrutides Phase 2 data also demonstrated robust improvements in blood pressure, fasting glucose, and triglycerides

Inflammation in obesity-related HFpEF: the STEPHFpEF program

Kidney Week, November 1520 (2016)