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It may take a few days under these circumstances
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GLP-1R V229A internalised more slowly than WT receptor after exendin-4 stimulation (Figure 6A-C), with only 10% of V229A internalised after 5-minutes stimulation versus 30% for WT

Response of blood glucose and GLP-1 to different food temperature in normal subject and patients with type 2 diabetes
In further support of a possibly limited role of native GLP1 in the control of ad libitum food intake, a number of studies have shown that GLP1producing PPG neurons are far less responsive to moderate food intake or gastric distension than neighbouring catecholaminergic neurons in the lower brainstem (Kreisler et al., 2014)
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This principle of gradual adjustment also applies when discontinuing the medication
