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Manish Sahni, MD at Centra Internal Medicine Does tirzepatide only reduce weight, or does it also improve metabolic health (blood sugar, cholesterol, etc.)

The appetite suppression is strong enough that you might need to consciously remind yourself to eat adequate nutrition and protein

This suggests tirzepatide may act directly on the brain rather than improving mood simply through weight change

Those experiencing nausea, vomiting, or diarrhea should be especially attentive to hydration status and may benefit from oral rehydration solutions containing electrolytes

LY3298176 was characterised in vitro, using signaling and functional assays in cell lines expressing recombinant or endogenous incretin receptors, and in vivo using body weight, food intake, insulin secretion and glycemic profiles in mice

However, both Trulicity and tirzepatide have been criticized by patients and their surviving family members because of the pancreatitis, vision loss, and gastroparesis that these drugs have caused