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B., Toutounchi H., et al., Efficacy and Safety of GlucagonLike Peptide1 Receptor Agonists for Weight Loss Among Adults Without Diabetes: A Systematic Review of Randomized Controlled Trials, Annals of Internal Medicine 178, no

another trial showed that 14% did not respond to semaglutide after 68 weeks

Taken together, in addition to some common benefits for CV systems, it is likely that GLP-1RAs improved overall CV outcomes mainly by reduction in atherosclerotic events, whereas SGLT2 inhibitors improved CV outcomes mainly via prevention of HF-related outcomes (Fig

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