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In each trial, participants are stratified by CSF sub-study participation (yes/no) to ensure 1:1 randomization in the sub-study population (Fig

Blood Sugar Control: Semaglutide and Tirzepatide: Both drugs provide strong blood sugar control, though Tirzepatides dual hormone action may offer a slight edge in regulating blood sugar

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Indeed, two randomized controlled trials showed that oral salsalate treatment decreased plasma glucose levels and insulin C-peptide, and increased plasma adiponectin levels in obese young adults 109 and in patients with impaired fasting glucose and/or impaired glucose tolerance