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Rabinovich-Nikitin I, et al

10.1136/bmj.q2440 BMJ

With regards to neurodegenerative diseases such as AD and PD, the literature has demonstrated the inhibitory effects of GLP-1 on pro-inflammatory cytokines such as TNF-alpha and IL-1betatwo notorious small molecules identified in the microglial-mediated injury observed in said diseases processes

Nausea is the most common, affecting 20-44% of semaglutide users in clinical trials

Phase 3 trials showed an average A1C drop of around 1.1% over 24 to 30 weeks

The observations that GLP-1 receptor agonists exert anti-inflammatory actions in preclinical studies, taken together with case reports linking improvements in psoriasis with GLP-1 receptor agonist therapy, illustrates the emerging clinical implications of non-classical anti-inflammatory actions of incretin-based therapeutics