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Wadden TA et al
In both trials, there was no difference in rates of nonfatal myocardial infarction and cardiovascular death between GLP-1 RA treated patients and placebo
.While clinical trials report no significant psychiatric risks, their exclusion of patients with mental health disorders limits generalizability
SGLT2 use was also associated with a slower annual rate of decline in eGFR, regardless of GLP-1 use at baseline
GLP-1 drugs are prescription-only and must be carefully dosed under medical supervision
\Metabolic Flexibility: Enhanced fat utilization and energy partitioning
