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Stress, hormonal cycles (particularly in women), and underlying metabolic conditions like insulin resistance can delay noticeable progress by one to two weeks

Adipocyte-specific Gipr ablation protects mice from HFD-induced insulin resistance and hepatic steatosis, potentially by reducing circulating levels of pro-inflammatory cytokines (68)

Sticking to the once-weekly regimen is key to avoiding spikes in medication levels that could increase side effects like nausea or dizziness

These two possible contributing causes need additional investigation

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