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[DOI] [PMC free article] [PubMed] [Google Scholar] [40].Kyriakidou A, Kyriazou AV, Koufakis T, et al

This leads to the subsequent cleavage of phosphatidylinositol 4,5-bisphosphate (PIP2) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP3)

The GIP receptor component enhances insulin secretion and may reduce nausea associated with GLP-1 activation

Glucagon receptor activation in the liver stimulates glycogenolysis and gluconeogenesis, but more relevantly for metabolic research, it also activates brown adipose tissue thermogenesis and increases fatty acid oxidation in hepatocytes

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