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Semaglutide is generally well-tolerated, but some mild side effects may occur, like nausea or headaches

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Orforglipron is a once-daily oral pill with FDA-approved strengths of 0.8 mg, 2.5 mg, 5.5 mg, 9 mg, 14.5 mg, and 17.2 mg

Patients enrolled in clinical trials should discuss any new or worsening symptoms with their trial team before self-managing with additional medications, to ensure there are no interactions or contraindications relevant to their specific trial protocol